- New York Giants play Washington Commanders
- Detroit Lions beat New England Patriots
- Kansas City Chiefs beat Atlanta Falcons
- Cleveland Browns beat Houston Texans*
- Green Bay Packers beat Minnesota Vikings
- Jacksonville Jaguars beat Tennessee Titans
- Miami Dolphins beat Indianapolis Colts*
- New Orleans Saints beat Carolina Panthers*
- Buffalo Bills beat New York Jets
- Seattle Seahawks beat Las Vegas Raiders
- Los Angeles Rams beat Arizona Cardinals
- San Francisco 49ers beat Dallas Cowboys
- Pittsburgh Steelers beat Cincinnati Bengals*
- Baltimore Ravens beat Los Angeles Chargers
Upset picks are marked with an asterisk. If I change any of my picks, the changes will be made before kickoff and specifically noted in an update to this post. The picks are also recorded at ESPN's Pick'em game.