Week 2 of the 2026 NFL season commences tomorrow night at the brand new Highmark Stadium in Orchard Park, New York, where the Buffalo Bills will host the Detroit Lions. Here are my picks (also visible at the "ESPN Pick'em" game site; I've created a "leaderboard" for anyone who wants to match their skills vs. mine).
- Detroit Lions beat Buffalo Bills*
- Carolina Panthers beat Atlanta Falcons
- Minnesota Vikings beat Chicago Bears*
- Philadelphia Eagles beat Tennessee Titans
- New England Patriots beat Pittsburgh Steelers
- Green Bay Packers beat New York Jets
- Tampa Bay Buccaneers beat Cleveland Browns
- Baltimore Ravens beat New Orleans Saints
- Houston Texans beat Cincinnati Bengals
- Jacksonville Jaguars beat Denver Broncos*
- Las Vegas Raiders beat Los Angeles Chargers*
- Dallas Cowboys beat Washington Commanders
- Seattle Seahawks beat Arizona Cardinals
- San Francisco 49ers beat Miami Dolphins
- Kansas City Chiefs beat Indianapolis Colts
- Los Angeles Rams beat New York Giants
"Upset" predictions -- predictions on which I disagree with the majority of ESPN Pick'em players -- are marked with asterisks. Any changes I make to my picks will be done prior to kickoff and noted below as well.
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