There is no question that some number of vaccines have had negative impacts on individuals. These may range from some temporary discomfort, to permanent disorders, to death. When people say vaccines are 'safe' I thus have to look at them like they are either ignorant or dishonest. Until vaccines are as safe as say, marijuana, calling them 'safe' as a blanket statement is just plain false. Vaccines do, in a small minority of cases, cause harm.
Every once in awhile, the guy makes me say to myself "damn ... I wish I had come up with that one."